Can very low carb ketogenic diets reverse kidney damage in diabetes? Possibly.
I came across this 2011 article in my trawling. Mice with diabetes and nephropathy (significant kidney damage) reversed their chemical derangements and partly reversed the changes at a cellular level.
Apart from better blood glucose control and a requirement for less medication, Ketogenic diets appear to have benefits at a renal level. Can anyone give me good reasons to NOT cutting back on carbohydrate intake in the management and prevention of Type 2 diabetes, and the management of Type 1?
Please don’t tell me it is unsustainable. That is just nonsense.
“Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy.
Having recently observed that the ketone 3-beta-hydroxybutyric acid (3OHB) reduces molecular responses to glucose, we hypothesized that a ketogenic diet, which produces prolonged elevation of 3-OHB, may reverse pathological processes caused by diabetes. …
Diabetic nephropathy, as indicated by albumin/creatinine ratios as well as expression of stress-induced genes, was completely reversed by 2 months maintenance on a ketogenic diet. However, histological evidence of nephropathy was only partly reversed.
These studies demonstrate that diabetic nephropathy can be reversed by a relatively simple dietary intervention. Whether reduced glucose metabolism mediates the protective effects of the ketogenic diet remains to be determined.”